GCT:
General:
Vascular sinuses lined or filled by gaint and spindle cells
3-4 decade
Locally agressive with recurrence of 30-50%
Eccentric, lytic, expansile lesion, cortical thinnning, associated soft tissue mass, well-or-poorly defined margins
Low on T1, high on T2
Malignant trasformation of GCT:
Rare
Most are secondary to radiotherapy
Osteosarcomatous transformation is the most common histological type, also
malignant fibrous histiocytoma and fibrosarcoma.
Reference:
1. Hughes et al. Benign primary tumours of the ribs. Clin rad (2006): 61:314-322
2. Heffernan EJ et al. Primary malignant transformation of giant cell tumor of bone. European Journal of Radiology Extra. Volume 62. June 2007, Pages 89-93
Journal watch:
1. Jong Won Kwon et al. MRI Findings of Giant Cell Tumors of the Spine. AJR 2007;189:246-250: Described in 10 patients, Typically expansile mass with heterogeneous low to intermediate signal on T2, curvilinear signal void on T1- and T2, cystic change; but no imaging feature is pathognomonic.
