Spindle cell and pleomorphic lipoma

Spindle cell lipoma Enzinger & Harvey (1975); Pleomorphic lipoma Shmookler & Enzinger (1981)
45 - 65 years with very common in men (90%)
Affects subcutaneous tissues of posterior neck, shoulder, back; also oral cavity, larynx, bronchus, breast, orbit, extremity. Deep ones are rare.
Commonly solitary, multiple are usually familial
Imaging shows fat and non-lipid component, which may enhance, hence difficult to differentiate from well differenitated liposarcoma
Surgical resected. Rarely recur, but no malignant potential

Murphey MD et al. Benign Musculoskeletal Lipomatous Lesions. RadioGraphics 2004;24:1433-1466