Rate of positive culture in histologically proven osteomyelitis is low (14%).
Aspirating more than 2 mL of purulent fluid is associated with higher rate of positive cultures.
References:
1. Wu JS et al. Imaging-Guided Bone Biopsy for Osteomyelitis: Are There Factors Associated with Positive or Negative Cultures? AJR 2007; 188:1529-1534
